Performance Evaluation of the LifeScale AST rapid Automated Antimicrobial Susceptibility System

Performance Evaluation of the LifeScale AST rapid Automated Antimicrobial Susceptibility System

Nanomechanical resonators enable the measurement of mass with extraordinary sensitivity1–7. Previously, samples as light as 7 zeptograms (1 zg510221 g) have been weighed in vacuum, and protonlevel resolution seems to be within reach8. Resolving small mass changes requires the resonator to be light and to ring at a very pure tone—that is, with a high quality factor9. In solution, viscosity severely degrades both of these characteristics, thus preventing many applications in nanotechnology and the life sciences where fluid is required10.

The emergence of drug-resistant microorganisms has increased the need for prompt and reliable antimicrobial susceptibility testing (AST). Rapid AST allows for quicker start of optimal therapy, which can improve patient outcomes and lower costs related to hospital stays. Currently, several platforms being developed deliver rapid AST results, however, rapid results may not improve patient care if they are not considered equivalent to standard results. Thus, the accuracy and reliability of results from rapid AST is of utmost importance. In this study, we assessed the performance of the new LifeScale rapid AST platform (Affinity Biosensors) that uses resonant mass measurements for calculation of antimicrobial susceptibility results.

Resolution of Antimicrobial Susceptibility Results Generated with a Five Hour Method Involving Polymicrobial Blood Cultures

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